Ss a ro ss b la rnp and sm are autoantigens commonly referred to as extractable nuclear antigens ena.
Ssa antibody normal range.
A positive anti ro result is revealed and known by a speckled appearance under immune fluorescence with ultraviolet light.
Sjogren s antibodies ss a ss b sjögren s antibodies ss b is detected in approximately 15 of patients with sjögren s syndrome.
Another condition called sjorgen s syndrome is also known to produce positive test results in up to 70 of people.
The presence of both antibodies ss a and ss b strengthen the diagnosis of sjögren s syndrome and conveys prognostic information.
In some regions however only 1 in 4 people with lupus will have a positive test result for this antibody.
Lower likelihood of anti dna antibodies.
Ss a ro antibodies are associated with childhood le neonatal le and with congenital heart block in infants born to mothers with le 1 2 ss a ro antibodies have also been reported to be associated with features of extraglandular inflammation in patients with le including vasculitis purpura cytopenias and adenopathy.
The reference range of anti ro antibodies is negative.
Sjögren s antibody ss b is present only if sjögren s antibody ss a is also detected.
25 of cases both anti ro ssa and.
Ss a ro is an extractable nuclear antigen ena composed of protein antigens of 52 kd and 60 kd combined with cytoplasmic rna species.
Anti ssa plus anti la ssb is associated with the following factors.
Ss a ro is composed of protein antigens of 52 kd and 60 kd combined with cytoplasmic rna species.
This has been termed antiphospholipid antibody syndrome.
Ss a ro antibodies occur in patients with several different connective tissue diseases including sjogren syndrome an autoimmune disease that involves primarily the salivary and lachrymal glands up to 90 of cases.
The reference range of anti ro antibodies is negative.
When anti ssa levels are elevated in sle it is often in antinuclear antibody ana negative lupus.
Antibodies to ena are common in patients with connective tissue diseases systemic rheumatic diseases.
Ss b la is composed of a 48 kd protein combined with rna species.
Anti ss a and anti ss b are found in virtually all children with neonatal lupus.
Ss b la antibodies are found primarily in patients with sjogren syndrome or le where they occur with frequencies of approximately 60 and 15 respectively 1 2 ss b la antibodies occur only infrequently in the absence of ss a ro antibodies.
Anti ro levels may be elevated in the following conditions.
Age older than 50 years.
Anti ro antibodies also known as anti ssa antibodies are associated with sjögren syndrome.
60 70 of cases systemic lupus erythematosus sle.
Anti ssa can be found in up to 60 of people who are confirmed to have lupus.
Ss a ro antibodies occur in patients with several different connective tissue.
Patients with ss a may also have antibodies to cardiolipin lupus anticoagulant and clinical thromboses.
